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Set in the heart of the historic town centre, there is evidence of a large Gallo-Roman villa on this site. Some traces remain, such as parts of the baths.
In the 15th century, Agnès Hugolen de Fos, a daughter of the Saint-Rémy nobility, married to a member of the great Provencal family de Sade, built a house on this site, which was substantially restored after 1945. The Hôtel de Sade belongs to the French Monuments Nationaux authority.